If you’re on the bleeding edge of DragonFly and already updated for Meltdown fixes, there’s a few more commits you’ll want to get.
Matthew Dillon wrote a summary of the current status, noting there’s not much you can do for Spectre beyond new hardware. There is an update to the “defensive browser setup” plan for DragonFly (using –site-per-process) that can help at least with Javascript versions of Spectre.
Update: step-by-step microcode fixes from Intel if you really want to trash your performance.